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- Part A and B A. What are the Hallmarks of Cancer? A) Criteria that are used to identify tumors in patientsB) Criteria that are used to classify cancers in patientsC) Criteria that must be met for cancer development and maintenanceD) Criteria that must be met to prevent cancer B. What is not a Hallmark of Cancer? A) Sustained proliferative signalingB) Sustained apoptosisC) ImmortalityD) AngiogenesisE) Evasion of growth suppressorsa) Mention the TNM classification of Cancer.?Ch. 7: Which of the following is FALSE about Wilms tumor? O a) it is a genetic condition, often affecting chromosome 3 or 11 or the X chromosome Ob) It is the most common type of kidney cancer in children. c) it usually initially occurs in one kidney O d) this condition has a poor long-term survival rate
- Name the six fundamental properties of malignant tumours. Which of these properties are amenable to study in a cell culture model of cancer and why?Select all of the sentences below that correctly describe the role of a healthy diet and lifestyle in cancer risk and progression. Select all that apply. A)Dietary supplements are definitively linked to lowering cancer risk. B)Consumption of processed meat containing nitrates and nitrites may increase a person’s risk of certain cancers. C)Grilling is a healthy cooking method; therefore, the consumption of all types of grilled meat will help reduce the risk of cancer. D)Folate may help reduce the incidence of colon cancer. E)Fruits and vegetables contain phytochemicals, antioxidants, and dietary fiber, all of which help reduce the risk of certain cancers.43. The drug vincristine, which prevents polymerization of tubulin, is used as a chemotherapeutic agent for a number of cancers. Its main mechanism of action in this context would be _______________in the cancer cells. a) blocking cell division by interfering with mitotic spindle formation b) disruption of cell shape or polarity c) disrupting cell function via abnormal localization of organelles d) a and c e) a, b and c
- 1. Describe & explain the pathophysiology of cancer based on the diagram. Reference: https://www.onlinebiologynotes.com/cancer-etiology-pathophysiology-types-diagnosis-and- treatment/ Acquired (environmental) DNA damaging agents: • chemical • radiation viruses Activation of growth- promoting oncogenes NORMAL CELL DNA Damage Failure of DNA repair Mutations in the genome of somatic cells Alteration of genes that regulate apoptosis Malignant neoplasm / Successful DNA repair CANCER Inherited mutations: • Genes affecting DNA repair • Genes affecting cell growth Expression of altered gene products and loss of regulatory gene products Inactivation of cancer suppresor genes Clonal expansion Additional mutations (progression) T HeterogeneityIdentify the major differences between benign and malignant tumors.Explain the local and systemic effects of cancer.
