31. A 6-year-old boy is brought to the physician by his mother because of intermittent upper abdominal pain during the past 5 weeks and a rash for 1 week. Vital signs are norm Physical examination shows yellow nodules over the extensor surfaces of the upper extremities. There is hepatomegaly and tenderness on palpation of the epigastric region Serum studies show an increased amylase activity, increased chylomicron concentration, and a markedly increased triglyceride concentration. Three months after beginnin restricted diet, his serum chylomicron and triglyceride concentrations decrease significantly, and the skin lesions resolve. A deficiency of which of the following enzymes is. likely cause of these findings? A OA) Acetyl-CoA carboxylase OB) HMG-CoA lyase OC) HMG-CoA reductase OD) Hormone-sensitive lipase OE) Lipoprotein lipase

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Chapter17: Drugs And Dissection
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31. A 6-year-old boy is brought to the physician by his mother because of intermittent upper abdominal pain during the past 5 weeks and a rash for 1 week. Vital signs are norma
Physical examination shows yellow nodules over the extensor surfaces of the upper extremities. There is hepatomegaly and tenderness on palpation of the epigastric regior
Serum studies show an increased amylase activity, increased chylomicron concentration, and a markedly increased triglyceride concentration. Three months after beginning
restricted diet, his serum chylomicron and triglyceride concentrations decrease significantly, and the skin lesions resolve. A deficiency of which of the following enzymes is
likely cause of these findings?
O A) Acetyl-CoA carboxylase
O B) HMG-CoA lyase
O C) HMG-CoA reductase
O D) Hormone-sensitive lipase
O E) Lipoprotein lipase
Transcribed Image Text:31. A 6-year-old boy is brought to the physician by his mother because of intermittent upper abdominal pain during the past 5 weeks and a rash for 1 week. Vital signs are norma Physical examination shows yellow nodules over the extensor surfaces of the upper extremities. There is hepatomegaly and tenderness on palpation of the epigastric regior Serum studies show an increased amylase activity, increased chylomicron concentration, and a markedly increased triglyceride concentration. Three months after beginning restricted diet, his serum chylomicron and triglyceride concentrations decrease significantly, and the skin lesions resolve. A deficiency of which of the following enzymes is likely cause of these findings? O A) Acetyl-CoA carboxylase O B) HMG-CoA lyase O C) HMG-CoA reductase O D) Hormone-sensitive lipase O E) Lipoprotein lipase
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