28. Sucrose in human nutrition is hydrolyzed into its monosaccharide components by sucrase. Glucose can enter directly in cellular respiration while fructose is predominantly metabolized in the liver as illustrated in the figure below. Suppose 180 molecules of sucrose are to be catabolized, what is the net ATP production during glycolysis considering both substrate-level phosphorylation and oxidative phosphorylation of NADH shuttled by malate and aspartate to the mitochondrion? [Hint: Sum of net ATP yield in substrate-level phosphorylation and ATP from glycolytic NADH] Fructose Glucose Glycogen ATP- ATP- ADP ADP+ hexokinase glucokinase Glucose-6-P→→→ Glucose-1-P Fructose-6-P Fructose-1,6-BP fructokinase rapid Fructose-1-P Rate aldolase B limiting Dihydroxyacetone-P Glyceraldehyde ATP- triose kinase ADP Glyceraldehyde-3-P Liver Also intestinal cells and kidney cortex PFK-1 Dihydroxy- acetone-P Lactate F1,6bisphosphatase Glyceraldehyde-3-P Pyruvate TCA cycle aldolase B (liver) aldolase A (muscle) ►Fatty acids

28. Sucrose in human nutrition is hydrolyzed into its monosaccharide components by sucrase. Glucose can enter directly in cellular respiration while fructose is predominantly metabolized in the liver as illustrated in the figure below. Suppose 180 molecules of sucrose are to be catabolized, what is the net ATP production during glycolysis considering both substrate-level phosphorylation and oxidative phosphorylation of NADH shuttled by malate and aspartate to the mitochondrion? [Hint: Sum of net ATP yield in substrate-level phosphorylation and ATP from glycolytic NADH] Fructose Glucose Glycogen ATP- ATP- ADP ADP+ hexokinase glucokinase Glucose-6-P→→→ Glucose-1-P Fructose-6-P Fructose-1,6-BP fructokinase rapid Fructose-1-P Rate aldolase B limiting Dihydroxyacetone-P Glyceraldehyde ATP- triose kinase ADP Glyceraldehyde-3-P Liver Also intestinal cells and kidney cortex PFK-1 Dihydroxy- acetone-P Lactate F1,6bisphosphatase Glyceraldehyde-3-P Pyruvate TCA cycle aldolase B (liver) aldolase A (muscle) ►Fatty acids

Concepts of Biology

1st Edition

ISBN:9781938168116

Author:Samantha Fowler, Rebecca Roush, James Wise

Publisher:Samantha Fowler, Rebecca Roush, James Wise

Chapter4: How Cells Obtain Energy

Section: Chapter Questions

Problem 17CTQ: Both prokaryotic and eukaryotic organisms carry out some form of glycolysis. How does ha fact...

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