25-year old man is admitted to the intensive care unitbecause of a severe episode of asthma that was responding to high dose nebulized bronchiodilators and corticosteriod therapy. He is currently intubated and mechanically ventilated. He is 170 cm ( 5 ft 7 inch) tall and weighs 80 kg( 176 Il); BMI is 28 kg/m2. Generalized inspiration and expiratory wheezes are heard on ausculation of the chest. Treatment with theophyline is considered possible therapy. If tha apparent distribution of theoophylline is 0.50 L/kg and the target plasma threophyline concentration to be achieved is 15 mg/L. the loading dose of intravenous theophylline that should be administered is closest to which of the following( in mg) A. 40 B 120 C 400 D. 600 E. 800 F. 1200
77/ A 25-year old man is admitted to the intensive care unitbecause of a severe episode of asthma that was responding to high dose nebulized bronchiodilators and corticosteriod therapy. He is currently intubated and mechanically ventilated. He is 170 cm ( 5 ft 7 inch) tall and weighs 80 kg( 176 Il); BMI is 28 kg/m2. Generalized inspiration and expiratory wheezes are heard on ausculation of the chest. Treatment with theophyline is considered possible therapy. If tha apparent distribution of theoophylline is 0.50 L/kg and the target plasma threophyline concentration to be achieved is 15 mg/L. the loading dose of intravenous theophylline that should be administered is closest to which of the following( in mg)
A. 40
B 120
C 400
D. 600
E. 800
F. 1200
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