22. For this question, you may want to analyze Fig. 16.25 on your book. Adrenaline stimulates glycogen breakdown in skeletal muscle cells by ultimately activating glycogen phosphorylase, the enzyme that breaks down glycogen, as depicted in the figure below. adrenaline Wi IT activated GPCR (adrenergic receptor) Answer: inactive phosphorylase kinase activated adenylyl cyclase inactive PKA ATP 1 CAMP ● ADP activated a subunit of stimulatory G protein (G) inactive glycogen phosphorylase active PKA GTP P .... ATP cyclic AMP ATP ADP CYTOSOL active phosphorylase kinase P active glycogen phosphorylase GLYCOGEN BREAKDOWN Which of the following statements is false? A) A constitutively active (i.e., always expressed) mutant form of PKA (cyclic AMP-dependent phosphorylase kinase) in skeletal muscle cells would lead to a decrease in the amount of unphosphorylated phosphorylase kinase. B) A constitutively active mutant form of PKA in skeletal muscle cells would not increase the affinity of adrenaline for the adrenergic receptor. C) A constitutively active mutant form of PKA in skeletal muscle cells would lead to an excess in the amount of glucose available. D) A constitutively active mutant form of PKA in skeletal muscle cells would lead to an excess in the amount of glycogen available. Explanation:
22. For this question, you may want to analyze Fig. 16.25 on your book. Adrenaline stimulates glycogen breakdown in skeletal muscle cells by ultimately activating glycogen phosphorylase, the enzyme that breaks down glycogen, as depicted in the figure below. adrenaline Wi IT activated GPCR (adrenergic receptor) Answer: inactive phosphorylase kinase activated adenylyl cyclase inactive PKA ATP 1 CAMP ● ADP activated a subunit of stimulatory G protein (G) inactive glycogen phosphorylase active PKA GTP P .... ATP cyclic AMP ATP ADP CYTOSOL active phosphorylase kinase P active glycogen phosphorylase GLYCOGEN BREAKDOWN Which of the following statements is false? A) A constitutively active (i.e., always expressed) mutant form of PKA (cyclic AMP-dependent phosphorylase kinase) in skeletal muscle cells would lead to a decrease in the amount of unphosphorylated phosphorylase kinase. B) A constitutively active mutant form of PKA in skeletal muscle cells would not increase the affinity of adrenaline for the adrenergic receptor. C) A constitutively active mutant form of PKA in skeletal muscle cells would lead to an excess in the amount of glucose available. D) A constitutively active mutant form of PKA in skeletal muscle cells would lead to an excess in the amount of glycogen available. Explanation:
Chapter27: Medications That Affect The Nervous System
Section: Chapter Questions
Problem 23RQ
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Question
Transcribed Image Text:22. For this question, you may want to analyze Fig. 16.25 on your book. Adrenaline stimulates glycogen breakdown in
skeletal muscle cells by ultimately activating glycogen phosphorylase, the enzyme that breaks down glycogen, as
depicted in the figure below.
adrenaline.
activated GPCR
(adrenergic receptor)
Answer: Explanation:
activated
adenylyl cyclase
inactive PKA
inactive
phosphorylase
kinase
ATP
CAMP
ADP
activated a subunit of
stimulatory G protein (G₁)
active PKA
inactive
glycogen
phosphorylase
GTP
ATP
cyclic AMP
ATP ADP
CYTOSOL
active
phosphorylase
kinase
active glycogen
phosphorylase
ELE
GLYCOGEN
BREAKDOWN
Which of the following statements is false?
A) A constitutively active (i.e., always expressed) mutant form of PKA (cyclic AMP-dependent phosphorylase
kinase) in skeletal muscle cells would lead to a decrease in the amount of unphosphorylated phosphorylase
kinase.
B)
A constitutively active mutant form of PKA in skeletal muscle cells would not increase the affinity of adrenaline for
the adrenergic receptor.
C)
A constitutively active mutant form of PKA in skeletal muscle cells would lead to an excess in the amount of
glucose available.
D) A constitutively active mutant form of PKA in skeletal muscle cells would lead to an excess in the amount of
glycogen available.
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