2. Uniparental disomy is a rare phenomenon in whichonly one of the parents of a child with a recessivedisorder is a carrier for that trait; the other parent ishomozygous normal. By analyzing DNA polymorphisms, it is clear that the child received both mutantalleles from the carrier parent but did not receive anycopy of the gene from the other parent.a. Diagram at least two ways in which uniparentaldisomy could arise. (Hint: These mechanismsall require more than one error in cell division,explaining why uniparental disomy is so rare.)Is there any way to distinguish between thesemechanisms to explain any particular case ofuniparental disomy?
2. Uniparental disomy is a rare phenomenon in whichonly one of the parents of a child with a recessivedisorder is a carrier for that trait; the other parent ishomozygous normal. By analyzing DNA polymorphisms, it is clear that the child received both mutantalleles from the carrier parent but did not receive anycopy of the gene from the other parent.a. Diagram at least two ways in which uniparentaldisomy could arise. (Hint: These mechanismsall require more than one error in cell division,explaining why uniparental disomy is so rare.)Is there any way to distinguish between thesemechanisms to explain any particular case ofuniparental disomy?
Human Biology (MindTap Course List)
11th Edition
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cecie Starr, Beverly McMillan
Chapter19: Introduction To Genetics
Section: Chapter Questions
Problem 9CT
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2. Uniparental disomy is a rare phenomenon in which
only one of the parents of a child with a recessive
disorder is a carrier for that trait; the other parent is
homozygous normal. By analyzing DNA polymorphisms, it is clear that the child received both mutant
alleles from the carrier parent but did not receive any
copy of the gene from the other parent.
a. Diagram at least two ways in which uniparental
disomy could arise. (Hint: These mechanisms
all require more than one error in cell division,
explaining why uniparental disomy is so rare.)
Is there any way to distinguish between these
mechanisms to explain any particular case of
uniparental disomy?
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