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1. Sickle cell is a lethal disease caused by being homozygous for the recessive sickle cell allele. Individuals that are affected have the genotype ss, while SS are totally unaffected and Ss are carriers of the allele, but also have an intermediate phenotype. Ss individuals do not die from sickle cell anemia because they have some normal erythrocytes and some sickled erythrocytes. This mode of inheritance is known as incomplete dominance because the dominant allele is not fully expressed over the recessive allele. With sickle cell disease being lethal in your late 20s, one would expect that the disease-causing alleles would quickly exit the population gene pool. However, in equatorial Africa, the allele persists and Ss individuals are common. In that part of the world, malaria caused by Plasmodium vivax is also relatively common. This organism infects erythrocytes causing malaria. Propose a hypothesis as to why the sickle cell allele persists in the population at that part of the world and why Ss individuals would have an advantage.

1. Sickle cell is a lethal disease caused by being homozygous for the recessive sickle cell allele. Individuals that are affected have the genotype ss, while SS are totally unaffected and Ss are carriers of the allele, but also have an intermediate phenotype. Ss individuals do not die from sickle cell anemia because they have some normal erythrocytes and some sickled erythrocytes. This mode of inheritance is known as incomplete dominance because the dominant allele is not fully expressed over the recessive allele. With sickle cell disease being lethal in your late 20s, one would expect that the disease-causing alleles would quickly exit the population gene pool. However, in equatorial Africa, the allele persists and Ss individuals are common. In that part of the world, malaria caused by Plasmodium vivax is also relatively common. This organism infects erythrocytes causing malaria. Propose a hypothesis as to why the sickle cell allele persists in the population at that part of the world and why Ss individuals would have an advantage.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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1. Sickle cell is a lethal disease caused by being homozygous for the recessive sickle cell allele. Individuals that are affected have the genotype ss, while SS are totally unaffected and Ss are carriers of the allele, but also have an intermediate phenotype. Ss individuals do not die from sickle cell anemia because they have some normal erythrocytes and some sickled erythrocytes. This mode of inheritance is known as incomplete dominance because the dominant allele is not fully expressed over the recessive allele. With sickle cell disease being lethal in your late 20s, one would expect that the disease-causing alleles would quickly exit the population gene pool. However, in equatorial Africa, the allele persists and Ss individuals are common. In that part of the world, malaria caused by Plasmodium vivax is also relatively common. This organism infects erythrocytes causing malaria. Propose a hypothesis as to why the sickle cell allele persists in the population at that part of the world and why Ss individuals would have an advantage.
Transcribed Image Text:1. Sickle cell is a lethal disease caused by being homozygous for the recessive sickle cell allele. Individuals that are affected have the genotype ss, while SS are totally unaffected and Ss are carriers of the allele, but also have an intermediate phenotype. Ss individuals do not die from sickle cell anemia because they have some normal erythrocytes and some sickled erythrocytes. This mode of inheritance is known as incomplete dominance because the dominant allele is not fully expressed over the recessive allele. With sickle cell disease being lethal in your late 20s, one would expect that the disease-causing alleles would quickly exit the population gene pool. However, in equatorial Africa, the allele persists and Ss individuals are common. In that part of the world, malaria caused by Plasmodium vivax is also relatively common. This organism infects erythrocytes causing malaria. Propose a hypothesis as to why the sickle cell allele persists in the population at that part of the world and why Ss individuals would have an advantage.
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