1. Explain BRIEFLY whether each of the following conditions will increase or decrease the chance of cancer: a. a mutation in the promoter region of a tumor suppressor gene that results in that gene being overexpressed (assume that the cell is heterozygous for the mutation) b. a mutation in the promoter region of a protooncogene that results in that gene being overexpressed (assume that the cell is heterozygous for the mutation) c. a homozygous mutation that completely eliminates the coding region of a protooncogene

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter12: Genes And Cancer
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Problem 15QP: Which of the following mutations will result in cancer? a. homozygous recessive mutation in a...
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1. Explain BRIEFLY whether each of the following conditions will increase or decrease the
chance of cancer:
a. a mutation in the promoter region of a tumor suppressor gene that results in that gene
being overexpressed (assume that the cell is heterozygous for the mutation)
b. a mutation in the promoter region of a protooncogene that results in that gene being
overexpressed (assume that the cell is heterozygous for the mutation)
c. a homozygous mutation that completely eliminates the coding region of a protooncogene
d. a homozygous mutation that completely eliminates the coding region of a tumor
suppressor gene
e. a heterozygote where one allele is the mutant allele described in (c), the other allele
being wild type
f.
a heterozygote where one allele is the mutant allele described in (d), the other allele
being wild type
Transcribed Image Text:1. Explain BRIEFLY whether each of the following conditions will increase or decrease the chance of cancer: a. a mutation in the promoter region of a tumor suppressor gene that results in that gene being overexpressed (assume that the cell is heterozygous for the mutation) b. a mutation in the promoter region of a protooncogene that results in that gene being overexpressed (assume that the cell is heterozygous for the mutation) c. a homozygous mutation that completely eliminates the coding region of a protooncogene d. a homozygous mutation that completely eliminates the coding region of a tumor suppressor gene e. a heterozygote where one allele is the mutant allele described in (c), the other allele being wild type f. a heterozygote where one allele is the mutant allele described in (d), the other allele being wild type
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