1) Proteins undergo a process called thermal denaturation. This is a process where the protein unfolds (denaturates) as the temperature is increased. (This has important practical consequences for protein based pharmaceuticals). Later this semester we will see that proteins can also denaturate if they are cooled too much. For now we will consider heat denaturation: Protein (folded) → Protein(unfolded) . For a certain protein Adenaturation H is 418.0 k.J mol¬! and Adenaturation S = 1.30 k.J K-1 mol-1. Assume that these values of Adenaturation H and Adenaturation S are independent of temperature (this is actually a bad assumption in real life). A) Calculate AdenaturationG at 310 K. Do you expect the thermal denaturation of the protein to be spontaneous? B) Does the entropy change favor the folded state or the unfolded state at 310 K? C) At what temperature is AdenaturationG zero? We usually call this temperature the “melting temperature" of the protein.
1) Proteins undergo a process called thermal denaturation. This is a process where the protein unfolds (denaturates) as the temperature is increased. (This has important practical consequences for protein based pharmaceuticals). Later this semester we will see that proteins can also denaturate if they are cooled too much. For now we will consider heat denaturation: Protein (folded) → Protein(unfolded) . For a certain protein Adenaturation H is 418.0 k.J mol¬! and Adenaturation S = 1.30 k.J K-1 mol-1. Assume that these values of Adenaturation H and Adenaturation S are independent of temperature (this is actually a bad assumption in real life). A) Calculate AdenaturationG at 310 K. Do you expect the thermal denaturation of the protein to be spontaneous? B) Does the entropy change favor the folded state or the unfolded state at 310 K? C) At what temperature is AdenaturationG zero? We usually call this temperature the “melting temperature" of the protein.
Introductory Chemistry: An Active Learning Approach
6th Edition
ISBN:9781305079250
Author:Mark S. Cracolice, Ed Peters
Publisher:Mark S. Cracolice, Ed Peters
Chapter22: Biochemistry
Section: Chapter Questions
Problem 55E: Although RNA is single-stranded, the strand sometimes folds back on itself to give a complementary...
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NOT a graded assignment. From my understanding it is just (Delta G) = (Delta H) - (T)(Delta S) for part A. I am confused about the "unfolding" part and the last part.
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