. Differentiate leukemia from lymphoma and myeloma as to: a. hallmark cells / blood features b. organ in the body affected 2. In the 6 factors related to the occurrence of leukemia, rank them in order in which you think is the most related (1 for most related, 6 for least related). Give the reason for your ranking. 3. Rationalize why most leukemic patient die of infection.

. Differentiate leukemia from lymphoma and myeloma as to: a. hallmark cells / blood features b. organ in the body affected 2. In the 6 factors related to the occurrence of leukemia, rank them in order in which you think is the most related (1 for most related, 6 for least related). Give the reason for your ranking. 3. Rationalize why most leukemic patient die of infection.

Cardiopulmonary Anatomy & Physiology

7th Edition

ISBN:9781337794909

Author:Des Jardins, Terry.

Publisher:Des Jardins, Terry.

Chapter6: Oxygen And Carbon Dioxide Transport

Section: Chapter Questions

Problem 8RQ

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1. Differentiate the acute leukemias from the chronic leukemias as to: a. maturational stage of cells that predominate in blood / bone marrow. b. chronologic type( life expectancy after diagnosis) 2. Contrast the bases of FAB classification of leukemias from the bases of WHO classification. 3. The stain for esterases are useful in differentiating 2 types of AML. Why do you think this is more valuable in differentiating myelogenous/granulocytic from monocytic cells.
ANSWER BRIEFLY PLEASE THANK YOU. 1. Differentiate leukemia from lymphoma and myeloma as to: a. hallmark cells / blood features b. organ in the body affected 2. In the 6 factors related to the occurrence of leukemia, rank them in order in which you think is the most related (1 for most related, 6 for least related). Give the reason for your ranking.
4. Indicate the hallmark / characteristics features in: a. CLL b. CML c. AML d. ALL 5. In hairy cell leukemias (HCL), tartrate resistant acid phosphatase is demonstrated. In your opinion, is this the most reliable test to diagnose HCL at present. Explain in not more than 3 sentences. 6. The use of monoclonal antibodies to detect cluster of differentiation (CD) in leukemic cells, mostly immature cells is common in the laboratory. Why do you think this is more valuable than morphological examination of cells in the blood/bone marrow cells. 7. Differentiate Hodgkin Lymphoma from Non-Hodgkin Lymphoma as to the life expectancy of the patients and degree of malignancy. 8. Compare polycythemia vera from essential thrombocythemia as to laboratory profile
7. Discuss the medical and nursing management of Leukemia.
7. Hematopoiesis refers to I Multipotent haematopoietic stem cells are involved in this process II. the production of RBCS within the red marrow cavities of the spongy bones III the formation of blood cells within the yellow marrow in the međullary cavities of bones IV. the formation of all of the cellular components of blood within the red marrow cavities of the spongy bones А. I В. IV C. both I and II D. both I and III E. both I and IV F. All choices are correct
26. On the photo below circle and label the cell of origin for each of the four subtypes of leukemia (AML, CML, ALL, CLL) Megakaryocyte Thrombocytes Common myeloid progenitor Erythrocyte Basophil Mast cell Multipotential hematopoietic stem cell (Hemocytoblast) Myeloblast Neutrophil Eosinophil myeloid blast cell Natural killer cell (Large granular lymphocyte) Monocyte Common lymphoid progenitor Macrophage Small lymphocyte T lymphocyte -CLL B lymphocyte Plasma cell 5
5. Imatinib, a tyrosine kinase inhibitor, has revolutionized the treatment of chronic myelogenous leukemia (CML). Explain 1) why individuals with CML respond well to imatinib, 2) the mechanism of action of imatinib, and 3) the impact of imatinib on CML outcome/survival.
9. Case Study: A male patient experienced body malaise, joint pains. He consulted a family medicine physician and was later referred to a hematologist, where bone marrow examination revealed a 10% plasma cells. Myeloma proteins and Bence- Jones protein were demostrated in the blood and urine respectively. a. Is the plasma cell count above, within or below normal/reference value? b. Give the reason why there is higher than normal myeloma proteins in the blood? c. Give the reason why a high level of Bence- Jones protein is detected in urine? d. On the basis of the laboratory results, what do you think is the disease/disorder of the patient?
23. Johnny was hospitalized in early August 2021 and diagnosed with Stage IV Lung Cancer even if he was a non-smoker). He went through 2 chemotherapy sessions, immunotherapy and radiotherapy but CT scans showed that the condition had gotten worse. Johnny was discharged from Sengkang General Hospital and was transferred to Assisi Hospice so he can receive palliative care for the remaining days of his life. What type of care was given to Johnny? A. Restorative Care B. End-of-life practice C. Long-Term Care D. Chronic Care 24. Progressive and long-term care facilities, therapeutic rehabilitation centers, and halfway houses provide which type of medical care? A. Restorative Care B. End-of-life practice C. Long-Term Care D. Chronic Care 25. What type of care is provided by Geriatric Day care centers and Nursing Homes? A. Restorative Care B. End-of-life practice C. Long-Term Care D. Tertiary Care
10. What is an anemia? 11. What is the genetic mutation associated with sickle cell? 12. Compare and contrast sickle cell disease versus sickle cell trait? Think about causes, age of diagnosis, signs and symptoms, when do these conditions become problematic to health? how might they differ on lab tests 13. In which populations and/or regions of the world does sickle cell disease and sickle trait most commonly appear? Speculate why this might be? 14. Define exertional sickling? Why is this relevant to the case study presented in class?
5. This may elevate the risk for cerebral microbleeds in patients with hemophilia a.All of the above b.Hepatitis C infection c.Increased age d.Cardiovascular risk factors 6. The prenatal counselling and delivery planning is discussed for a pregnant with hemophilia. Which of the following statements is true: a.Vaginal delivery is recommended based on the low overall risk of bleeding with vaginal delivery in a neonate with severe hemophilia b. The patients should have maternal factor levels drawn regardless of planned delivery route c. Cesarean delivery is recommended based on the increased risk of intracerebral hemorrhage associated with a trial of labor d. None of the choices
3-Which of the following is TRUE about sickle cell disease (SCD)? Select all that apply. A. Sickle cell anemia (SCD) is an inherited disorder of the hemoglobin in blood. B. Sickle cell anemia requires the inheritance of two sickle cell genes. C. Sickle cell trait, which is the inheritance of one sickle gene, almost never causes problems. D. Virtually all of the major symptoms of sickle cell anemia are the direct result of the abnormally shaped sickled red blood cells obstructing the flow of blood. E. all that apply 4-In children diagnosed with sickle cell disease (SCD), tissue damage results from which of the following? A. Air hunger and respiratory alkalosis due to deoxygenated red blood cells. B. Hypersensitivity of the central nervous system (CNS) due to elevated serum bilirubin levels C. A general inflammatory response due to an autoimmune reaction from hypoxia D. Local tissue damage with ischemia and necrosis due to obstructed circulation