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Why do the individuals with genetic defects in C4 have a strong propensity to develop autoimmune diseases?
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- Is Crohn's disease considered as an autoimmune disease. If it is, are there other predisposing factors to it other than genetics? If it is not, what is its nature?What is the difference between an allergy and an autoimmune response?What is the genetic component most strongly associated with autoimmune disorders?
- What is chronic inflammation and how is it mediated?How is chronic inflammation related to autoimmune diseases? explain at your own wordsThe circulating cytokines that recruit large numbers of phagocytes to the area of inflammation, resulting in pus, are called: O1) pyogens O 2) pyrogens 3) interferons O 4) defensins29 - 30. An allergy is caused when a person's immune system overreacts to a normally harmless substance, such as plant pollen, dust, or pet dander. Substances that trigger an allergic reaction are called allergens. An allergic reaction is triggered when the immune system recognizes an allergen as foreign and tries to destroy it by releasing histamines, much like it would if it encountered a harmful virus or bacteria. Histamines cause localized swelling, and result in allergy symptoms such as itchy eyes, a runny nose, and sneezing. Which statement best explains how an allergen causes an allergic reaction? a. The initial exposure to the allergen causes a negative feedback mechanism in the immune system to become overactive and leads to the release of histamines that destroy immune cells. b. Prolonged exposure to the allergen interferes with a negative feedback loop in the immune system, which results in the immune system releasing histamines more aggressively with increased allergen…