The following compound undergoes nucleophile aromatic substitution (NAS). Draw the curved arrow. mechanism including the intermediate and product. Your arrows must indicate the specific flow of electrons. 0=18 NaO-CH₂ ONE CH₂
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- rank these from least to most reactive in nucleophilic acyl substitution with a nucleophile I)CH3COOC2H5 II) CH3COO-Na+ III)CH3COCl IV) CH3CONH2Which of the following would be a better starting material for a nucleophilic aromatic substitution reaction? Explain your choice using structures. Then provide the complete arrow pushing mechanism for the reaction of the better starting material and excess ethanol. CI CI O₂N NO₂ NO₂ NO₂Usually at the 2- or 3- position, Thiophene undergoes electrophilic aromatic substitution. Draw the intermediates and all resonance structures for the reaction at each position, and then decide what position should be more reactive depending on your intermediates.
- Predict the major product of the given reaction and then draw a reasonable mechanism for the product formation using appropriate curved arrow notation. Part 1: OH H2SO4 (aq) view structure Part 2 out of 4 H,0 H,SO4 HSO, HO finish structure . draw structure . H;O*Consider the SN2 reaction of butyl bromide with OH- ion. CH3CH2CH2CH2B + OH- → CH3CH2CH2CH2OH + Br Assuming no other changes, what effect on the rate would result from simultaneously doubling the concentrations of both butyl bromide and the OH- ion? Draw the curved arrow mechanism for the SN1 reaction of methanol with tert-butyl iodide. Next, draw an Energy vs. Reaction Coordinate diagram for this reaction, labeling all transition states as "TS" and intermediates as appropriate for those drawn in the mechanism above, showing the relative energies on the diagram.Correct H3C CH3 H3O+ O CH3 H3C OH CH3 CH3 CH2CO2H This reaction involves a hydrolysis followed by an intramolecular nucleophilic acyl substitution reaction. Write out the reaction on a separate sheet of paper, and then draw the structure of the hydrolysis products.
- In order to complete the synthesis shown below, you would need to use [ Select ] as the nucleophile source and [Select] as the solvent. H3C OH H3C Br H3CY CH3 H3C CH3Each of the following may participate in an elimination reaction, under the proper conditions. (a) Circle the alpha (a) carbon. (b) Circle the beta (B) carbon(s). (c) Draw the alkene product(s) that may form, with the new double bond between the a and ß positions. (d) If more than one alkene product is possible, circle the most stable (Zaitsev) product. A В J C K E F G 33-0The compound below can be prepared with an alkyl iodide and a suitable nucleophile. Identify the alkyl iodide and the nucleophile that you would use. For an anionic nucleophile, you do not need to draw the counterion. Alkyl iodide: OH Draw Your Solution Nucleophile: Draw Your Solution SUPPORT
- Be sure to answer all parts. Predict the major product of the given reaction and then draw a reasonable mechanism for the product formation using appropriate curved arrow notation. Part 1 out of 4 H2SO4 (aq) draw structure .Complete the following nucleophilic substitution reactions. In each reaction, show all electron pairs on both the nucleophile and the leaving group.On a scrap piece of paper, draw the curved arrow mechanism for the following reaction. Once you have determined the major product, draw it in the space below. 1) Ph MgCl, Et₂O 2) NH,C, H,O