Please fill in the four boxes bolded belowKM (MM)Vmax (nM/s)Type of inhibition11(Competitive/Noncompetitive/Uncompetitive)Ki (mm)2Noinhibitor23Inhibitor A(1 mM)12 constar23the rateInhibitor B(1 mM)2223

Competitive inhibitors are the substances which are similar to substrate molecules in their…

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Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter9: Parenteral Medication Labels And Dosage Calculation

Section: Chapter Questions

Problem 6.4P

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Calculate, or make a best estimate of, the unknown factors in the situations listed in Table 1. Table 1. Data for problem 1. To find Data (i) Ek [K+]out = 4 mM; [K+]in = 130 mM (ii) [Cl-]in [Cl-]out = 570 mM; ECl = -65 mV (iii) ECl [Cl-]out = 150 mM; [Cl-]in = 8 mM; in a mammal (iv) [Na+]in Overshoot of action potential = +35 mV; saline [Na+] = 112 mM (v) [K+]in Blood [K+] = 3.2 mM; undershoot of action potential = -87 mV (vi) ECa [Ca2+]out = 5.6 mM; free [Ca2+]in = 0.8 mM (vii) [K+]out [K+]in = 350 mM; Ek = -82 mV
Two peptides, A and B were tested for activity against Enzyme X, a poison found in the venom of marine snail, to determine if they can be used as antidote for the poison. The results are summarized in the table below: Velocity, mM/min IS). mM No inhibitor SmM Peptide A SmM Peptide B 1.0 2.5 1.17 0.77 2.0 4.0 2.10 1.25 5.0 6.3 4.00 2.00 10.0 7.6 5.70 2.50 20.0 9.0 7.20 2.86 1. Determine the Km and Vmax for the inhibited and uninhibited reactions 2. What types of inhibition are shown by Peptides A and B? 3. Calculate the Ki for Peptide A and Peptide B. Assume [1) = 2.5 x 10-3 M 4. Which is a better inhibitor for Enzyme X? Explain briefly.
rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1
What is the approximate rate of change of A340 measured? i.e. ΔA340 / min = __________ What rate of change of A340 would you predict if 30 ml of the ADH solution was tested in the same way (i.e. half the amount of protein) ? i.e. ΔA340 / min = __________ What rate of change of A340 would you predict if 60 ml of a 0.5 μM ADH solution was tested in the same way? i.e. ΔA340 / min = __________ As well as writing your answers, explain your reasoning.
Consider the following experimental data from another experiment: [S] 1.5 2.00 2.50 5.00 10.00 V (No inhibitor) mmol ml¹ min¹ 0.167 0.204 0.232 0.313 0.385 V (inhibitor) mmol ml¹¹ min¹¹ 0.115 0.143 0.167 0.250 0.333 Calculate Km and V max and determine whether this inhibitor is competitive, non-competitive or uncompetitive.
MAP= CO x TPR / 80 I don't understand the value of TPR how do I get this number?
An experiment was carried out to measure the reaction rate of hydrolysis of acetylcholme (substrate) with serum enzymes (Eadie, 1949). In the experiment, two experiments were conducted, namely experiment 1 without using a prostigmine inhibitor and experiment 2 using a prostigmine inhibitor at 1.5 x 10^-7 mol/l. the data obtained are: a. Is prostigmine competitive or noncompetitive inhibitor? b. determine the value of km and rmax for the two experiments, compare
Figure 1: Concentration of water samples used to determine urine glucose levels in diamond tetras (Moenkhausia pittieri), with and without exposure to 0.5 I.U./mL insulin. Aquarium water samples were collected at room temperature at 0, 30, 60, and 90 minutes. Concentration values were calculated by obtaining the absorbance (570 nm) of the water samples using a spectrophotometer and compared to a standard curve for glucose to extrapolate the concentration of each sample. Concentration values are plotted with error bars that represent the standard deviation of the concentration levels. 1) how would you describe the trends of this graph in a paragraph asap please
Iodine-131 is commonly used for the treatment of Graves' disease, which is a disease of the thyroid gland. The number of 131I used depends on the size of the patient's thyroid gland. If the dosage for 131I is 86 microcuries per gram of the thyroid gland, and assuming all the iodine given will accumulate in the thyroid gland, then: a. What activity dose of 131I should be given to a patient who has a thyroid gland weighing 15 grams?b. What is the value of the decay rate constant I-131 if the half-life = 8.07 days?c. How many grams of 131I to give?d. How many grams of 131I are left in the patient after 1 month?
2) After plotting actin bound to cofilin versus the cofilin concentration, you generate the figure below. v (cofilin binding density) 1 0.8 0.6 0.4 0.2 0 2 4 6 8 [S. pombe cofilin] free (UM) 10 a) What is the Kd you measure for this interaction? b) What is the AG of the interaction? c) Based on the data, is there anything you suspect about the binding of protein and ligand?
The top panel (a) of this figure shows the graded potential change (far right, upper, electrical trace) that results from ligand binding to the ligand gated Na+ channel. The bottom panel of this figure (b) shows a graded potential change (far right, lower, electrical trace) that results from ligand binding to a ligand gated Cl- channel. From this trace you know (Vm = -70 mV) 1. ECl- is -70 mV 2. ECl- is more negative than -70 mV (i.e., -80 mV) 3. ECl- is more positive than -70 mV (i.e., -60 mV)
1000 Tablets 48, Kandivli Ind Estate, Mumbai 400 067, India by: Ipca Laboratories Limited Jacksonville, FL 32257 USA Ranbaxy Pharmaceuticals Inc. Manufactured for Rx only LOT: EXP: 100 mg TABLETS, USP ALLOPURINOL N Each scored tablet contains: Allopurinol, USP........100 mg Store at 20° to 25°C (68° to 77° F) [See USP Controlled Room Temperature]. Dispense in tight, light-resistant container as defined in the USP. USUAL DOSE: One tablet daily. For indications, dosage, precautions, etc., see accompanying package insert. Code: DNH/DRUGS/NH/170 3 633041153910 NDC 63304-539-10 Non varnish area R RANBAXY LBZTL6 0311 Expiration date Prescription warning Total amount in vial, packet, box Usual adult dose Dosage strength Drug form Lot number (control number) National Drug Code (N D C) # Manufacturer Brand name Generic name

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Please fill in the four boxes bolded below you KM (MM) Vmax (nM/s) Type of inhibition (Competitive/Noncompetitive/Uncompetitive) Ki (mm) 2 No inhibitor 23 Inhibitor A (1 mM) 12 SETTO 23 Inhibitor B (1 mM) 22 23