Gierke disease (glycogenosis) arises in the inherited defect of glucose-6- phosphatase and is accompanied by swelling of liver and hypoglycemia in postabsorptive period. Why does a fasting blood glucose level of patients fall sharply in the morning? To answer this question: a) draw the scheme of the mobilization of the main reserve homopolysaccharide involving glucose-6-phosphatase in a healthy person and indicate the localization of this process in the organism; b) explain the role of this metabolic pathway.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Gierke disease (glycogenosis) arises in the inherited defect of glucose-6-
phosphatase and is accompanied by swelling of liver and hypoglycemia in
postabsorptive period. Why does a fasting blood glucose level of patients fall
sharply in the morning? To answer this question:
a) draw the scheme of the mobilization of the main reserve homopolysaccharide
involving glucose-6-phosphatase in a healthy person and indicate the localization
of this process in the organism;
b) explain the role of this metabolic pathway.

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