An allele causes homozygous individuals to die before birth. The allele is continuously being generated in the population by loss of function mutations within a gene that is important for mitosis and meiosis. Heterozygotes for the allele experience a reduction in fitness because 5% of heterozygotes are sterile. The remaining 95% of heterozygotes and all homozygotes for the wild-type allele are fertile and viable. The frequency of the allele amongst individuals at birth is 1/5000. A. What is the rate of mutation that creates this allele? B. What is the average fitness of individuals in the population? C. What is the average fitness of individuals from a mating between first cousins?

Human Biology (MindTap Course List)
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Author:Cecie Starr, Beverly McMillan
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Chapter19: Introduction To Genetics
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An allele causes homozygous individuals to die before birth. The allele is continuously
being generated in the population by loss of function mutations within a gene that is
important for mitosis and meiosis. Heterozygotes for the allele experience a reduction in
fitness because 5% of heterozygotes are sterile. The remaining 95% of heterozygotes and
all homozygotes for the wild-type allele are fertile and viable. The frequency of the allele
amongst individuals at birth is 1/5000.
A. What is the rate of mutation that creates this allele?
B. What is the average fitness of individuals in the population?
C. What is the average fitness of individuals from a mating between first cousins?
D. The decrease in fitness from inbreeding can be calculated as:
Winbred
1-
Woutbred
What is the average decrease in fitness from inbreeding between cousins for this
mutation in this population?
Transcribed Image Text:An allele causes homozygous individuals to die before birth. The allele is continuously being generated in the population by loss of function mutations within a gene that is important for mitosis and meiosis. Heterozygotes for the allele experience a reduction in fitness because 5% of heterozygotes are sterile. The remaining 95% of heterozygotes and all homozygotes for the wild-type allele are fertile and viable. The frequency of the allele amongst individuals at birth is 1/5000. A. What is the rate of mutation that creates this allele? B. What is the average fitness of individuals in the population? C. What is the average fitness of individuals from a mating between first cousins? D. The decrease in fitness from inbreeding can be calculated as: Winbred 1- Woutbred What is the average decrease in fitness from inbreeding between cousins for this mutation in this population?
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