Figure 19.25 shows that the Sxl protein binds to the mRNA of the msl-2 gene, inhibiting translation of the mRNA’s proper reading frame. The MSL-2 protein is a transcription factor that binds to the X chromosome in XY males to double the level of X-linked gene transcription, thus equalizing X-linked gene expression in XY males and XX females.a. In which sex, XY males or XX females, would the Sxl protein bind to the msl-2 mRNA?b. As discussed in Problem 35, some Sxl alleles are lethal to females and others are lethal to males. Is the function of Sxl in regulating the synthesis of Msl-2 protein sufficient to explain the sex-specific lethality caused by both kinds of alleles?c. Predict the effect of loss-of-function mutations in msl-2 on male and female fertility and viability. Figure 19.25 Translational regulation by a decoy AUG.To prevent translation of msl-2 mRNA in Drosophila females, Sxlprotein (green) binds to the MRNA and causes the ribosome (blue)to translate the uORF. Sxl protein thus prevents translationof the main ORF that encodes Msl-2 protein.5'Ribosome recognizesmsl-2 mRNAupstream AUGNo translationAUG Main ORF Stop of main ORFAUG ) SxlAAAAAUpstream ORF 36. Figure 19.25 shows that the Sxl protein binds to themRNA of the msl-2 gene, inhibiting translation of theMRNA's proper reading frame. The MSL-2 protein isa transcription factor that binds to the X chromosomein XY males to double the level of X-linked genetranscription, thus equalizing X-linked gene expres-sion in XY males and XX females.a. In which sex, XY males or XX females, would theSxl protein bind to the msl-2 MRNA?b. As discussed in Problem 35, some Sxl alleles arelethal to females and others are lethal to males. Isthe function of Sxl in regulating the synthesis ofMsl-2 protein sufficient to explain the sex-specific lethality caused by both kinds of alleles?c. Predict the effect of loss-of-function mutationsin msl-2 on male and female fertility andviability.

Name: Figure 19.25 shows that the Sxl protein binds to the mRNA of the msl-2
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Description: Figure 19.25 shows that the Sxl protein binds to the mRNA of the msl-2 gene, inhibiting translation of the mRNA’s proper reading frame. The MSL-2 protein is a transcription factor that binds to the X chromosome in XY males to double the level of X-li

Drosophila sex determination and dosage compensation are primarily controlled by two distinct sets…

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Figure 19.25 shows that the Sxl protein binds to the mRNA of the msl-2 gene, inhibiting translation of the mRNA’s proper reading frame. The MSL-2 protein is a transcription factor that binds to the X chromosome in XY males to double the level of X-linked gene transcription, thus equalizing X-linked gene expression in XY males and XX females. a. In which sex, XY males or XX females, would the Sxl protein bind to the msl-2 mRNA? b. As discussed in Problem 35, some Sxl alleles are lethal to females and others are lethal to males. Is the function of Sxl in regulating the synthesis of Msl-2 protein sufficient to explain the sex-specific lethality caused by both kinds of alleles? c. Predict the effect of loss-of-function mutations in msl-2 on male and female fertility and viability.

Figure 19.25 Translational regulation by a decoy AUG.
To prevent translation of msl-2 mRNA in Drosophila females, Sxl
protein (green) binds to the MRNA and causes the ribosome (blue)
to translate the uORF. Sxl protein thus prevents translation
of the main ORF that encodes Msl-2 protein.
5'
Ribosome recognizes
msl-2 mRNA
upstream AUG
No translation
AUG Main ORF Stop of main ORF
AUG ) Sxl
AAAAA
Upstream ORF

36. Figure 19.25 shows that the Sxl protein binds to the
mRNA of the msl-2 gene, inhibiting translation of the
MRNA's proper reading frame. The MSL-2 protein is
a transcription factor that binds to the X chromosome
in XY males to double the level of X-linked gene
transcription, thus equalizing X-linked gene expres-
sion in XY males and XX females.
a. In which sex, XY males or XX females, would the
Sxl protein bind to the msl-2 MRNA?
b. As discussed in Problem 35, some Sxl alleles are
lethal to females and others are lethal to males. Is
the function of Sxl in regulating the synthesis of
Msl-2 protein sufficient to explain the sex-
specific lethality caused by both kinds of alleles?
c. Predict the effect of loss-of-function mutations
in msl-2 on male and female fertility and
viability.

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